Detecting Axion-Like Particles With Gamma Ray Telescopes

We propose that axion-like particles (ALPs) with a two-photon vertex, consistent with all astrophysical and laboratory bounds, may lead to a detectable signature in the spectra of high-energy gamma ray sources. This occurs as a result of gamma rays being converted into ALPs in the magnetic fields of efficient astrophysical accelerators according to the "Hillas criterion", such as jets of active galactic nuclei or hot spots of radio galaxies. The discovery of such an effect is possible by GLAST in the 1-100 GeV range and by ground based gamma ray telescopes in the TeV range.Comment: corrected typos, one plot modified, material rearranged for clarification. Conclusions unchanged. Matches version published in Phys. Rev. Let

GRB Flares: UV/Optical Flaring (Paper I)

We present a new algorithm for the detection of flares in gamma-ray burst (GRB) light curves and use this algorithm to detect flares in the UV/optical. The algorithm makes use of the Bayesian Information Criterion (BIC) to analyze the residuals of the fitted light curve, removing all major features, and to determine the statistically best fit to the data by iteratively adding additional `breaks' to the light curve. These additional breaks represent the individual components of the detected flares: T_start, T_stop, and T_peak. We present the detection of 119 unique flaring periods detected by applying this algorithm to light curves taken from the Second Swift Ultraviolet/Optical Telescope (UVOT) GRB Afterglow Catalog. We analyzed 201 UVOT GRB light curves and found episodes of flaring in 68 of the light curves. For those light curves with flares, we find an average number of ~2 flares per GRB. Flaring is generally restricted to the first 1000 seconds of the afterglow, but can be observed and detected beyond 10^5 seconds. More than 80% of the flares detected are short in duration with Delta t/t of < 0.5. Flares were observed with flux ratios relative to the underlying light curve of between 0.04 to 55.42. Many of the strongest flares were also seen at greater than 1000 seconds after the burst.Comment: Submitted to ApJ. 20 pages (including 8 figures and 1 table

Invariant measures on multimode quantum Gaussian states

We derive the invariant measure on the manifold of multimode quantum Gaussian states, induced by the Haar measure on the group of Gaussian unitary transformations. To this end, by introducing a bipartition of the system in two disjoint subsystems, we use a parameterization highlighting the role of nonlocal degrees of freedom -- the symplectic eigenvalues -- which characterize quantum entanglement across the given bipartition. A finite measure is then obtained by imposing a physically motivated energy constraint. By averaging over the local degrees of freedom we finally derive the invariant distribution of the symplectic eigenvalues in some cases of particular interest for applications in quantum optics and quantum information.Comment: 17 pages, comments are welcome. v2: presentation improved and typos corrected. Close to the published versio

On the equipartition of thermal and non-thermal energy in clusters of galaxies

Clusters of galaxies are revealing themselves as powerful sources of non thermal radiation in a wide range of wavelengths. In order to account for these multifrequency observations equipartition of cosmic rays (CRs) with the thermal gas in clusters of galaxies is often invoked. This condition might suggest a dynamical role played by cosmic rays in the virialization of these large scale structures and is now testable through gamma ray observations. We show here, in the specific case of the Coma and Virgo clusters, for which upper limits on the gamma ray emission exist, that equipartition implies gamma ray fluxes that are close or even in excess of the EGRET limit, depending on the adopted model of CR injection. We use this bound to limit the validity of the equipartition condition. We also show that, contrary to what claimed in previous calculations, the equipartition assumption implies gamma ray fluxes in the TeV range which can be detectable even by currently operating gamma ray observatories if the injection cosmic ray spectrum is flatter than $E^{-2.4}$.Comment: 20 pages + 2 figures. To appear in the Astrophysical Journa

Velocity fluctuations of noisy reaction fronts propagating into a metastable state: testing theory in stochastic simulations

The position of a reaction front, propagating into a metastable state, fluctuates because of the shot noise of reactions and diffusion. A recent theory [B. Meerson, P.V. Sasorov, and Y. Kaplan, Phys. Rev. E 84, 011147 (2011)] gave a closed analytic expression for the front diffusion coefficient in the weak noise limit. Here we test this theory in stochastic simulations involving reacting and diffusing particles on a one-dimensional lattice. We also investigate a small noise-induced systematic shift of the front velocity compared to the prediction from the spatially continuous deterministic reaction-diffusion equation.Comment: 5 pages, 5 figure

Correlated Nanoscopic Josephson Junctions

We discuss correlated lattice models with a time-dependent potential across a barrier and show how to implement a Josephson-junction-like behavior. The pairing occurs by a correlation effect enhanced by the symmetry of the system. In order to produce the effect we need a mild distortion which causes avoided crossings in the many-body spectrum. The Josephson-like response involves a quasi-adiabatic evolution in the time-dependent field. Besides, we observe an inverse-Josephson (Shapiro) current by applying an AC bias; a supercurrent in the absence of electromotive force can also be excited. The qualitative arguments are supported by explicit exact solutions in prototype 5-atom clusters with on-site repulsion. These basic units are then combined in ring-shaped systems, where one of the units sits at a higher potential and works as a barrier. In this case the solution is found by mapping the low-energy Hamiltonian into an effective anisotropic Heisenberg chain. Once again, we present evidence for a superconducting flux quantization, i.e. a Josephson-junction-like behavior suggesting the build-up of an effective order parameter already in few-electron systems. Some general implications for the quantum theory of transport are also briefly discussed, stressing the nontrivial occurrence of asymptotic current oscillations for long times in the presence of bound states.Comment: 12 pages, 2 figures, to appear in J. Phys. - Cond. Ma

Latanoprost with high precision, piezo-print microdose delivery for IOP lowering: clinical results of the PG21 study of 0.4 µg daily microdose.

Background:Topical high-precision piezo-print delivery of microdoses of latanoprost achieved significant IOP reduction consistent with the eyedropper effect but with a 75% reduced exposure to drugs and preservatives. Prostaglandin analogs are a mainstay glaucoma therapy. However, conventional eyedroppers deliver 30-50 µL drops that greatly exceed the physiologic 7-µL ocular tear film capacity. Eyedropper overdosing floods the eye with excess drug compounds and preservatives, resulting in ocular surface toxicity, periorbitopathy, and other well-characterized ocular side effects. Piezoelectric high-precision microdosing provides targeted delivery that can reduce exposure to both drug and preservatives compared to conventional eyedropper delivery, with the potential to deliver similar biologic effect. Methods:Both eyes (N=60) of 30 healthy volunteers received single 8-µL microdoses of 0.005% latanoprost (0.4 µg; µRx-latanoprost) on the morning of Days 1 and 2 using a high-precision, piezo-print horizontal delivery system. Diurnal IOP was measured before and 2 days after microdosing. Main efficacy outcomes were diurnal IOP change after µRx-latanoprost microdosing and accurate microdosing success rates, and the primary safety outcome was adverse event (AE) incidence. Results:µRx-latanoprost reduced baseline IOP by 26% and 30% at 1 and 2 days postadministration, respectively. Successful topical dosing was achieved in 100% of technician-assisted deliveries. All patients successfully self-administered microdoses after receiving training. Microdose administration was well tolerated and did not result in any AEs. Conclusion:Microdosing of 0.4 µg of µRx-latanoprost achieved significant IOP reduction. Lower ocular exposure with topical prostaglandin analog microdosing can enable new therapeutic opportunities for optimizing glaucoma treatment. Microdosing may also be beneficial in reducing ocular side effects associated with excessive drug product and preservatives often used to treat chronic ocular diseases such as glaucoma